Tumor-Immune Interaction, Surgical Treatment, and Cancer Recurrence in a Mathematical Model of Melanoma
Figure 10
Metastatic growth under different values of .
The primary tumor is held to a steady state by the immune response, and metastases are seeded beginning 6 months into the simulation. For the lowest value of , a single metastatic lesion forms; moderate to high values lead to suppression of all metastases, while a very high
overwhelms the immune response, leading to widespread metastatic growth. Note that in (C) and (D) the immune response to the metastases can cause perturbations in the primary tumor size, but does not change the overall behavior. (A)
. (B)
. (C)
. (D)
.