Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved
Figure 2
Calculation of association rate constants using FoldX and comparison with experimental asoociation rate constants.
(A) Ras-Raf complex at different ionic strength (salt concentrations form 0 to 800 mM NaCl) (Table S1, [48]). The correlation coefficient is 0.987. (B) The Ras-RalGDS complex. Mutations within the RalGDS domain were introduced, and compared with experimental data (Table S1, [43]). The correlation coefficient is 0.892.