Entropy Measures Quantify Global Splicing Disorders in Cancer
Figure 2
Ratio of average isoform entropy in cancer versus normal tissues.
A value of 1 indicates that average entropy per gene in cancer tissue = average entropy per gene in normal tissue. The first number in parentheses corresponds to the number of genes that were used to calculate entropy gains, and the second corresponds the total coverage in ESTs/cDNAs/SAGEs for the diseased and normal tissue types. Only tissue types for which at least 50 genes and 100 isoforms were available to measure the entropy ratio are shown. (A) alternative initiation. (B) Alternative polyadenylation. (C) Alternative splicing.