Susceptibility to Superhelically Driven DNA Duplex Destabilization: A Highly Conserved Property of Yeast Replication Origins
Figure 5
(A) Replication timing profile of Chromosome 3. The two peaks indicated by red stars are predicted with high confidence to contain replication origins. (Data replotted from [23].)
(B and C) SIDD profiles of the two peak regions (from [A]) are plotted to high resolution, along with locations of the known ARS element (red) and the DNA segments within which ORC and MCM proteins were shown to bind [22] (yellow). (B) shows the profile around ARS 310, and (C) shows that of ARS 314.