Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth
Fig 1
TAL1 gene codes for 6 mRNA isoforms that translate to 2 protein isoforms.
(A) Schematic representation of TAL1 mRNA isoforms. Rectangles: exons, black lines: introns; arrow: transcription initiation site, coordinates corresponds to genome build hg19. (B) Schematic representation of TAL1 protein isoforms; grey rectangles represent the protein domain bHLH. (C) CutLL1, MOLT4, CCRF-CEM, Jurkat, and K562 whole cell lysate was extracted and subjected to western blot analysis using TAL1 antibody recognizing both isoforms and an endogenous control. (D) ChIP-seq tracks for H3K27ac and H3K4me3 at the TAL1 locus in the indicated cell lines (genome build hg19). Underlying data can be found in S1 Raw Images.