Longitudinal deep sequencing informs vector selection and future deployment strategies for transmissible vaccines
Fig 2
Relationships between strain genetic diversity, geographic range, and prevalence suggest strain emergence, spatial diffusion, and replacement.
Predicted relationships between strain-specific prevalence and (A) strain nucleotide diversity, (B) geographic range, and (C) the number of strains present in each geographic group sampled (a measure of potential competition between strains). Lines and shaded areas represent the regression slope and 95% confidence intervals, respectively. Points are raw data, corresponding to the observed prevalence of each strain in each group where it occurred, with point size proportional to sample size (range = 2 to 24). The dashed lines on each graph show the null expectation, averaged over 1,000 tip randomisations. Data underlying this figure can be found in S2 Data.