RanBP2/Nup358 Potentiates the Translation of a Subset of mRNAs Encoding Secretory Proteins
Figure 9
A general model of ALREX-regulated processes.
(1) mRNAs containing ALREX-promoting SSCRs are packaged into mRNPs and exported by an unknown mechanism. (2) The exported mRNAs transiently interact with RanBP2 at the cytoplasmic face of the nuclear pore. This interaction likely causes some alteration within the mRNP. (3) Ultimately, this interaction promotes the translation of these mRNAs into secretory proteins at the surface of the ER.