Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning
Figure 10
Neto1-Null Mice Have Impaired Spatial Learning and Memory
(A) Latency to find the platform of wild-type (n = 9) and Neto1-null mice (n = 9) in the Morris water maze task at each day of training. During pretraining, escape latency to find a visible-cued (V) platform located in the northeast (NE) quadrant was unaffected by genotype. Similarly, in the acquisition phase (days 1–6), escape latency to find a hidden platform located in the southeast (SE) quadrant was unaffected by genotype. In the second acquisition phase (days 7–9), Neto1-null mice had longer escape latencies when the hidden platform was relocated to the northwest (NW) quadrant (effect of genotype: F1,16= 5.50, p < 0.05; genotype × day interaction: F2,32 = 4.17, p < 0.05).
(B) Histogram of percent time spent in each quadrant after the first acquisition phase. T, target quadrant.
(C) Histogram of percent time spent in each quadrant after the second acquisition phase. Neto1-null mice spent significantly less time in the new target quadrant (NW) than wild-type littermates (effect of genotype: F1,16 = 9.75, p < 0.01). Data are shown as mean ± standard error of the mean (SEM).