Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae
Figure 5
Network characteristics of capacitor singletons
(A) The clustering coefficient (left) and betweenness centrality (right) of all nonessential singletons (light green) and capacitor singletons (light blue).
(B) Properties of the immediate PPI neighbors of a gene controlled for the degree of that gene (FDN score, see methods) for all nonessential singletons (light green) and capacitor singletons (light blue). From left to right: the phenotypic potential, the number of essential genes, the fraction of SLIs in the literature-curated BioGRID network, the haploid growth rate when deleted, the diploid growth rate when both copies are deleted. Error bars represent the standard error of the mean. Wilcoxon-Mann-Whitney test: *, p < 0.05; **, p < 0.01.