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Variant Histone H2A.Z Is Globally Localized to the Promoters of Inactive Yeast Genes and Regulates Nucleosome Positioning

Figure 5

H2A.Z Is Unusually Localized in HZAD Genes

(A) The raw (green) and smoothed (red) H2A.Z/H2B log2 ratios, as determined by our microarray experiment, are shown across a 5-KB region around the GIT1 genes. The genes present in that region are shown in blue.

(B) Same as (A) but for a 5-KB region around the SRB8 gene.

(C) H2A.Z covers wider regions near telomeres. The size of the regions covered by H2A.Z (as determined by distance between the coordinates where the smoothed H2A.Z/H2B log2 ratio reaches “0.1”) is plotted against the distance to telomeres. A moving average (window = 10 KB) was applied to the data.

Figure 5

doi: https://doi.org/10.1371/journal.pbio.0030384.g005