Preferential Duplication of Conserved Proteins in Eukaryotic Genomes
Figure 5
Correcting for Synonymous Substitutions Reveals That S. cerevisiae Genes That Have Recently Duplicated Have a Higher Codon Bias and Slower Rate of Evolution Than Those That Duplicated in the Ancient Past
For duplicate genes in S. cerevisiae, moving averages of the number of nonsynonymous substitutions per nonsynonymous site of representative pairs (KA, in dark gray), the codon bias in S. cerevisiae (CAI, in black), and the codon bias of representative pairs in D. melanogaster (CAI, in light gray) are plotted against the adjusted number of synonymous substitutions per site (see Materials and Methods) between duplicate pairs. The bin size is 15, and standard error bars are shown. Lines with broad dashes show the respective averages for singleton genes in S. cerevisiae, and the line with short dashes shows the average KA for representative pairs of duplicate genes in C. elegans.