In this work, we present a monolithic 3D printing process which integrates liquid-state printed components and interconnects with readily available silicon IC chips in all three dimensions, various orientations and multiple printing layers to deliver system-level functionalities. Our process allows for personalization of objects with electronic capabilities through incorporation of various sensing, actuation and circuit functionalities within 3D complex architectures. As an example application, our process can be used to develop physical assisting and therapeutic devices, a form-fitting glove with embedded programmable heater and “earable” device for real-time detection of core body temperature, that need to be tailored to the patient’s needs and body. Such levels of personalization and 3D integration of system-level functionalities into objects, as enabled by our process, are well aligned with the vision of Internet of Things.