We developed smart biodevices to measure action potential of artificial tissue structures. In recent days, biodevieces to measure biological information are strongly required for drug discovery, improvement of quality of life (QOL) of patient and other bioengineering fields. Biocompatible flexible sensors are fabricated utilizing printed electronics technology. Artificial tissue structures are fabricated utilizing cell sheet technology, bioprint technology, and other biofabrication technologies. When the flexible sensors are set on artificial tissue structure, then action potential of the artificial tissue structure was measured. In this presentation, we show results of the developed biodevices.