Pleural mesothelioma in a California sea lion (Zalophus californianus)

Yuki TAKAMI; Miyuu TANAKA; Masahiro MORITA; Takaya MARUNO; Naohiro ANAI; Tsubasa SUDO; Chiho KEZUKA; Takeshi IZAWA; Jyoji YAMATE; Mitsuru KUWAMURA

doi:10.1292/jvms.22-0457

Wildlife Science

Pleural mesothelioma in a California sea lion (Zalophus californianus)

Yuki TAKAMI, Miyuu TANAKA, Masahiro MORITA, Takaya MARUNO, Naohiro ANAI, Tsubasa SUDO, Chiho KEZUKA, Takeshi IZAWA, Jyoji YAMATE, Mitsuru KUWAMURA

Author information

Yuki TAKAMI
Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan
Miyuu TANAKA
Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan
Masahiro MORITA
Katsurahama Aquarium, Inside Katsurahama Park, Kochi, Japan
Takaya MARUNO
Katsurahama Aquarium, Inside Katsurahama Park, Kochi, Japan
Naohiro ANAI
Katsurahama Aquarium, Inside Katsurahama Park, Kochi, Japan
Tsubasa SUDO
Kobe Municipal Suma Aqualife Park, Hyogo, Japan
Chiho KEZUKA
Kobe Municipal Suma Aqualife Park, Hyogo, Japan
Takeshi IZAWA
Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan
Jyoji YAMATE
Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan
Mitsuru KUWAMURA
Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan

Keywords: California sea lion, mesothelioma, pleura, tuberculosis

JOURNAL OPEN ACCESS
Supplementary material

2023 Volume 85 Issue 9 Pages 1030-1033

DOI https://doi.org/10.1292/jvms.22-0457

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Abstract

A 25-year-old female California sea lion (Zalophus californianus) reared in an aquarium died following a history of anorexia, lethargy, abnormal protrusion of the skin, and oral respiration. At necropsy, multiple yellowish-white nodules with diameters of 0.1–0.5 cm were disseminated in the thoracic cavity and lungs. Histopathologically, the nodules were continuous with normal mesothelium and were characterized by the proliferation of spindle-shaped to polygonal neoplastic cells with prominent atypia. The neoplastic cells exhibited diffuse, strong staining for vimentin and partial, weak to moderate staining for cytokeratin AE1/AE3. Based on these findings, the lesions were diagnosed as pleural mesothelioma. This study reports the first case of pleural mesothelioma in California sea lion.

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