Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)

Rui KANO; Meika TSUNOI; Yumiko NAKAYA; Takashi NAGAMINE; Koji ONO

doi:10.1292/jvms.20-0380

Internal Medicine

Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)

Rui KANO, Meika TSUNOI, Yumiko NAKAYA, Takashi NAGAMINE, Koji ONO

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Keywords: antifungal susceptibility tests, Aspergillus flavus, avian aspergillosis, Okinawa rail, low-susceptibility

JOURNAL OPEN ACCESS

2021 Volume 83 Issue 1 Pages 28-30

DOI https://doi.org/10.1292/jvms.20-0380

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Abstract

A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.

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