The authors examined the effects of RU486 on the In Vitro fertilization (IVF) of hamsters. Six groups of medium containing 1, 5, 10, 20, 40 and 60 μM RU486 were prepared. In the control group without RU486, the fertilization rate was 97.3%. In the 1 μM RU486 group, the fertilization rate was 94.6%, and the difference between the control and 1 μM RU486 groups was not significant. In the remaining 5, 10, 20, 40 and 60 μM RU486 groups, the fertilization rate decreased in a concentration-dependent manner, and in the 60 μM RU486 group, it was reduced to 56.3% (P<0.001). These results showed that RU486, an antagonist of progesterone, inhibited IVF of hamsters in a concentration-dependent manner.

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