Cyanide-resistant respiration was induced in Hansenula anomala in the presence of various sulfur compounds, having no inhibitory effect on the normal cytochrome pathway. This induction was observed in the presence of glucose. The mitochondrial 36kDa protein responsible for cyanide-resistant respiration was also detected in the cells where cyanide-resistant respiration was induced by oxidized glutathione, indicating that there might be a common mechanism to initiate the biosynthesis of the protein. All the inducing conditions are deduced to increase the generation of superoxide anion, and some radical scavengers inhibited the induction, suggesting the possible involvement of certain active oxygen species in the initial induction process.

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