Leucomycin A¹ (LM A₁) was converted to leucomycin A₃ (LM A₃) by Streptomyces kitasatoensis is glucose-containing medium. On the other hand, butyrate, one of the pre-cursors of the aglycone, repressed the bioconversion of LM A_l to A₃. The role of butyrate has been examined in connection with that of glucose. It was found that the production of the enzyme which catalyzes the acetylation at C-3 of aglycone was induced by glucose, and that the induction was remarkably repressed by butyrate. Cerulenin, a specific inhibitor of fatty acid synthesis, was effectively employed for the bioconversion experiments.

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