In the present report, the relationships among three genetic markers, purine, tryptophan dependence and strpetomycin resistance, and the activities of adenosine formation from adenine by Bacillus subtilis Marburg are described. Purine or tryptophan independent strain was obtained by means of transformation and streptomycin sensitive strains by back mutation from B. subtilis Marburg 160-88 which is able to produce adenosine from adenine. It is pointed out that the higher adenosine formation is related only to purine dependent maker and not to tryptophan dependent and streptomycin resistant markers.

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