A molecular weight of 980 was determined for fungisporin by the isothermal distillation method. In view of information published previously¹⁾ this points to a formula (Val, Phe)₄ for this compound. Sequence studies on peptide fragments, obtained from fungisporin by partial acid hydrolysis, led to the structural formula cyclo-(Val₂•Phe₂)₂ for this natural cyclic polypep-tide. Enzymatic experiments with the peptides obtained, showed that the full formula of fungi-sporin is most probably cyclo-(D-Val•L-Val•D-Phe•L-Phe•)₂.

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