CORRELATION BETWEEN THE ACTIVITY OF NEUTROPHIL PHOSPHATASES AND GLYCOSYLATED HAEMOGLOBIN LEVELS IN DIABETIC PATIENTS

NICOLAS TSAVARIS; GERASSIMOS A. PANGALIS; PARIS KOSMIDIS; KOSTANTINOS KONSTANTOPOULOS; ELENI VARIAMI; MANOLIS GANOTAKIS; ELIAS TSOUTSOS; GEORGE DIMITRIADIS; SOTIRIS RAPTIS

doi:10.1267/ahc.24.329

NICOLAS TSAVARIS, GERASSIMOS A. PANGALIS, PARIS KOSMIDIS, KOSTANTINOS KONSTANTOPOULOS, ELENI VARIAMI, MANOLIS GANOTAKIS, ELIAS TSOUTSOS, GEORGE DIMITRIADIS, SOTIRIS RAPTIS

Author information

NICOLAS TSAVARIS
Second Department of Medical Oncology, “Metaxa” Cancer Hospital
GERASSIMOS A. PANGALIS
First Department of Internal Medicine, “Laiko” General Hospital, University of Athens School of Medicine
PARIS KOSMIDIS
Second Department of Medical Oncology, “Metaxa” Cancer Hospital
KOSTANTINOS KONSTANTOPOULOS
First Department of Internal Medicine, “Laiko” General Hospital, University of Athens School of Medicine
ELENI VARIAMI
First Department of Internal Medicine, “Laiko” General Hospital, University of Athens School of Medicine
MANOLIS GANOTAKIS
Second Department of Internal Medicine-Propaedeutic, “Evagelismos” Hospital, University of Athens, School of Medicine
ELIAS TSOUTSOS
Second Department of Medical Oncology, “Metaxa” Cancer Hospital
GEORGE DIMITRIADIS
Second Department of Internal Medicine-Propaedeutic, “Evagelismos” Hospital, University of Athens, School of Medicine
SOTIRIS RAPTIS
Second Department of Internal Medicine-Propaedeutic, “Evagelismos” Hospital, University of Athens, School of Medicine

JOURNAL FREE ACCESS

1991 Volume 24 Issue 3 Pages 329-334

DOI https://doi.org/10.1267/ahc.24.329

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Abstract

The activity of polymorphonuclear neutrophil phosphatases; neutrophil alkaline phosphatase (NAP), neutrophil acid phosphatase (NAcP), neutrophil glucose-6-phosphatase (NG6P), and neutrophil 5-nucleotidase (N5N), was determined cytochemically in correlation to glycosylated hemoglobin (HbA_1c) levels. The percentages of positive neutrophils on blood smears for these enzymes were estimated in three groups: in diabetic (HbA_1c>8.0%), well-controlled diabetic (HbA_1c<8.0%) patients, and in normal controls. Statistical difference in the activities of NAP and NG6P was found between diabetic and well-controlled diabetic patients, as well as normal controls. In fact, in uncontrolled diabetic patients with higher HbA_1c, NAP shows a higher positive percentage whereas NG6P grows lower ones. Any other examined enzymes do not show such alterations. Any difference between well-controlled diabetic patients and normal controls was recognized in all the examined enzymes.

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