1978 年 98 巻 5 号 p. 660-663
Comparative examinations were made on palmitic acid, which has an anti-inflammatory effect, and myristic acid, which has no such effect, for their incorporation into various tissues and body fluids in intact and granuloma pouch rats by oral administration of 14C-labeled fatty acids. In intact rats, significantly higher radioactivity was found in the heart, liver, spleen, and adrenals 2 hr after administration of 1-14C-palmitic acid, compared to that in the group given 1-14C-myristic acid. This trend continued for 24 hr. In granuloma pouch-bearing rats, radioactivity showed a significantly higher distribution in the adrenals and pouch exudate 2 hr after 14C-palmitic acid administration, compared to the group given myristic acid. This tendency continued for 24 hr. However, radioactivity in the pouch wall showed higher distribution in the rats given 14C-myristic acid.