Steroid化合物の研究 (第2報)
16-Oxygenated Steroidに関する研究 その2 16α-Methyl-16β,17β-dihydroxysteroidの合成
1960 年 80 巻 3 号 p. 327-329
詳細
1960 年 80 巻 3 号 p. 327-329
Grignard reaction of 16-oxoestradiol 3-methyl ether (Ia) with methylmagnesium iodide gave 16α-methyl-3-methoxy-1, 3, 5(10)-estratriene-16β, 17β-diol (IIa), which formed 16, 17-acetonide (IIIa) by the action of acetone and hydrogen chloride. Hydrolysis of (IIIa) with hydrochloric acid in dioxane reverted it to (IIa). Similarly, 16-oxoestradiol diacetate (Ic) afforded the glycol (IIc) and its 16, 17-acetonide (IIIc), and 3β, 17β-diacetoxy-5-androsten-16-one (IV) formed the glycol (V) and its 16, 17-acetonide (VI).
