By the Reissert reaction of 4-substituted quinoline-N-oxides, 4-substituted quinaldic nitriles are obtained easily and in a good yield. The latter were utilized in the syntheses of quinaldic diethylaminoethylamides having methoxyl, ethoxyl, n-propoxy, and n-butoxy radicals in the 4-position. Comparative tests of the local anesthetic actions of these compounds with percaine were the objective.