YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
動物体内に於ける枝鎖脂肪酸の運命 (第4報)
天然炭素数領域に於ける脂肪酸の酸化開裂に就いて
山川 民夫
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ジャーナル フリー

1950 年 70 巻 11 号 p. 633-637

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In order to understand the oxidation cleavage of fatty acids in which the number of carbon atoms is in the range of those appearing in nature, 2-propylmyristic acid was given to rabbits and 2-propyladipic acid was recovered from their urine. Comparing this result with the works carried out by earlier researchers, a hypothesis of ζ-oxidation was proposed. However, when the rabbits were given 2-propyltridecanoic acid, from their urine was recovered a mixture of acids in 70-30 gravimetric proportions of 2-propylglutaric and 2-propylpimelic acids by which the possibility of ζ-oxidation was completely lost. It was further confirmed that branched-chain fatty acids possessing 16-17 C-atoms underwent ω-oxidation at first, then β-oxidation, finally liberating the two C-atom fragments from the end.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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