Unusual Detritylation of Tritylated Tetrazole in Sartan Molecules

Sankareswaran Srimurugan; Paulsamy Suresh; Balaji Babu; Salmara Ganeshbhat Hiriyanna; Hari Narayan Pati

doi:10.1248/cpb.56.383

Notes

Unusual Detritylation of Tritylated Tetrazole in Sartan Molecules

Sankareswaran Srimurugan, Paulsamy Suresh, Balaji Babu, Salmara Ganeshbhat Hiriyanna, Hari Narayan Pati

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Keywords: tritylamine, deprotection, detritylation, sartan molecule, tetrazole

JOURNAL FREE ACCESS

2008 Volume 56 Issue 3 Pages 383-384

DOI https://doi.org/10.1248/cpb.56.383

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Abstract

Tritylated tetrazole of 2a underwent unusual detritylation under basic reaction condition during the synthesis of methyl ether of olmesartan medoxomil 1. The unusual detritylation was found to be a common feature in the case of all tetrazole containing Sartan molecules (3—7).

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