Tricalysiosides P—U: Ent-kaurane Glucosides and a Labdane Glucoside from Leaves of Tricalysia dubia O<small>HWI</small>

Hideaki Otsuka; Junko Shitamoto; Dong-Hui He; Katsuyoshi Matsunami; Takakazu Shinzato; Mitsunori Aramoto; Yoshio Takeda; Tripetch Kanchanapoom

doi:10.1248/cpb.55.1600

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Tricalysiosides P—U: Ent-kaurane Glucosides and a Labdane Glucoside from Leaves of Tricalysia dubia OHWI

Hideaki Otsuka, Junko Shitamoto, Dong-Hui He, Katsuyoshi Matsunami, Takakazu Shinzato, Mitsunori Aramoto, Yoshio Takeda, Tripetch Kanchanapoom

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Keywords: Tricalysia dubia, Rubiaceae, diterpenoid, tricalysioside, ent-kaurane glucoside, labdane glucoside

JOURNAL FREE ACCESS

2007 Volume 55 Issue 11 Pages 1600-1605

DOI https://doi.org/10.1248/cpb.55.1600

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Abstract

Further extensive isolation work on the 1-BuOH-soluble fraction of a MeOH extract of Tricalysia dubia afforded five new ent-kaurane glucosides (4—8) and one new labdane glucoside (9), together with a known megastigmane glucoside, sammangaoside B (1), and monoterpene glucosides (2, 3). The structures of the new compounds were elucidated by analyses of one- and two-dimensional NMR spectroscopic data. The absolute configuration of the 9-position of sammangaoside B was revised to S and its total stereochemistry was established by the modified Mosher's method.

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