α-Glucosidase Inhibitory and Antioxidant Acridone Alkaloids from the Stem Bark of Oriciopsis glaberrima E<small>NGL</small>. (Rutaceae)

Jean Duplex Wansi; Jean Wandji; Luc Mbaze Meva'a; Alain François Kamdem Waffo; Rose Ranjit; Shamsun Nahar Khan; Azaz Asma; Choudhary Muhammad Iqbal; Marie-Christine Lallemand; François Tillequin; Zacharias Fomum Tanee

doi:10.1248/cpb.54.292

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α-Glucosidase Inhibitory and Antioxidant Acridone Alkaloids from the Stem Bark of Oriciopsis glaberrima ENGL. (Rutaceae)

Jean Duplex Wansi, Jean Wandji, Luc Mbaze Meva'a, Alain François Kamdem Waffo, Rose Ranjit, Shamsun Nahar Khan, Azaz Asma, Choudhary Muhammad Iqbal, Marie-Christine Lallemand, François Tillequin, Zacharias Fomum Tanee

Author information

Jean Duplex Wansi
Department of Chemistry, University of Douala
Jean Wandji
Department of Organic Chemistry, University of Yaoundé I
Luc Mbaze Meva'a
Department of Chemistry, University of Douala
Alain François Kamdem Waffo
Department of Chemistry, University of Douala
Rose Ranjit
H.E.J. Research Institute of Chemistry, University of Karachi
Shamsun Nahar Khan
H.E.J. Research Institute of Chemistry, University of Karachi
Azaz Asma
H.E.J. Research Institute of Chemistry, University of Karachi
Choudhary Muhammad Iqbal
H.E.J. Research Institute of Chemistry, University of Karachi
Marie-Christine Lallemand
Laboratoire de Pharmacognosie UMR N° 8638 Université René-Descartes, Faculté des Sciences Pharmaceutiques et Biologiques
François Tillequin
Laboratoire de Pharmacognosie UMR N° 8638 Université René-Descartes, Faculté des Sciences Pharmaceutiques et Biologiques
Zacharias Fomum Tanee
Department of Organic Chemistry, University of Yaoundé I

Keywords: Oriciopsis glaberrima, oriciacridone C, oriciacridone F, α-glucosidase, antioxidant

JOURNAL FREE ACCESS

2006 Volume 54 Issue 3 Pages 292-296

DOI https://doi.org/10.1248/cpb.54.292

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Abstract

The CH₂Cl₂/MeOH extract of the stem bark of Oriciopsis glaberrima ENGL. afforded four new acridone alkaloids namely oriciacridone C, D, E and F along with six known compounds: atalaphyllidine, oleanolic acid, butulinic acid, β-sitosterol, stigmasterol, glucoside of stigmasterol and one synthetically known acridone: 1,3,5-trihydroxy-4-prenylacridone. The structures were established on the basis of MS, 1D and 2D NMR experiments. The acridones 1, 4 and 5 showed potent activity against α-glucosidase, while the acridones 1—5 showed moderate free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).

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