Synthesis of 2-Substituted Trifluoromethylquinolines for the Evaluation of Leishmanicidal Activity

Joël DADE; Olivier PROVOT; Henri MOSKOWITZ; Joëlle MAYRARGUE; Eric PRINA

doi:10.1248/cpb.49.480

Notes

Synthesis of 2-Substituted Trifluoromethylquinolines for the Evaluation of Leishmanicidal Activity

Joël DADE, Olivier PROVOT, Henri MOSKOWITZ, Joëlle MAYRARGUE, Eric PRINA

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Keywords: leishmaniasis, 2-propyltrifluoromethylquinoline, 2-epoxypropyltrifluoromethylquinoline, 2-(propen-1-yl)-trifluoromethylquinoline

JOURNAL FREE ACCESS

2001 Volume 49 Issue 4 Pages 480-483

DOI https://doi.org/10.1248/cpb.49.480

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Abstract

The synthesis of 2-substituted-trifluoromethylquinolines from aniline, trifluoromethylanilines, 3-aminoquinoline and trifluoromethylquinaldines is reported. In vitro antileishmanial evaluation of 2-alkyl, 2-alkenyl and 2-epoxypropyl-trifluoromethylquinolines is presented.

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