Synthesis of Extremely Simplified Compounds Possessing the Key Pharmacophore Units of Taxol, Phenylisoserine and Oxetane Moieties

Kaoru FUJI; Yukari WATANABE; Tadamune OHTSUBO; Mohammad NURUZZAMAN; Yoshio HAMAJIMA; Michiaki KOHNO

doi:10.1248/cpb.47.1334

Kaoru FUJI, Yukari WATANABE, Tadamune OHTSUBO, Mohammad NURUZZAMAN, Yoshio HAMAJIMA, Michiaki KOHNO

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Keywords: taxol, oxetane, phenylisoserine, biological activity, tubulin

JOURNAL FREE ACCESS

1999 Volume 47 Issue 9 Pages 1334-1337

DOI https://doi.org/10.1248/cpb.47.1334

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Abstract

Straight chain compounds having a phenylisoserine unit and an oxetane ring at the α- and ω-position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.

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