Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocurcumenone, and Curcarabranols A and B : Vasorelaxant Activity of Zedoary Sesquiterpenes

Masayuki YOSHIKAWA; Toshiyuki MURAKAMI; Toshio MORIKAWA; Hisashi MATSUDA

doi:10.1248/cpb.46.1186

Masayuki YOSHIKAWA, Toshiyuki MURAKAMI, Toshio MORIKAWA, Hisashi MATSUDA

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Keywords: carabrane-type sesquiterpene, absolute stereostructure, curcumenone, curcarabranol, vasorelaxant effect, zedoary

JOURNAL FREE ACCESS

1998 Volume 46 Issue 7 Pages 1186-1188

DOI https://doi.org/10.1248/cpb.46.1186

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Abstract

New carabrane-type sesquiterpenes, curcarabranols A and B, were isolated from zedoary together with the two known carabrane-type sesquiterpenes curcumenone and 4S-dihydrocurcumenone. The absolute stereostructures of these carabrane-type sesquiterpenes were determined on the basis of physicochemical and chemical evidence. Zedoary sesquiterpenes including 4S-dihydrocurcumenone and curcarabranols A and B were found to inhibit the contraction induced by a high concentration of K⁺ in isolated rat aortic strips.

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