Marine Natural Products. XXXIV. Trisindoline, a New Antibiotic Indole Trimer, Produced by a Bacterium of Vibrio sp. Separated from the Marine Sponge Hyrtios altum

Motomasa KOBAYASHI; Shunji AOKI; Katsuhiko GATO; Katsuyoshi MATSUNAMI; Michio KUROSU; Isao KITAGAWA

doi:10.1248/cpb.42.2449

Marine Natural Products. XXXIV. Trisindoline, a New Antibiotic Indole Trimer, Produced by a Bacterium of Vibrio sp. Separated from the Marine Sponge Hyrtios altum

Motomasa KOBAYASHI, Shunji AOKI, Katsuhiko GATO, Katsuyoshi MATSUNAMI, Michio KUROSU, Isao KITAGAWA

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Keywords: trisindoline, Vibrio sp., marine sponge, Hyrtios altum, antibiotic, indole trimer

JOURNAL FREE ACCESS

1994 Volume 42 Issue 12 Pages 2449-2451

DOI https://doi.org/10.1248/cpb.42.2449

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Abstract

A new antibiotic indole trimer named trisindoline (1) was isolated, together with a known dioxopiperazine brevianamide F (2), from the culture of a bacterium of Vibrio sp., which was separated from the Okinawan marine sponge Hyrtios altum. The structure of trisindoline (1) has been determined on the bases of physicochemical evidence and chemical synthesis.

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