5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines

Shoichiro OZAKI; Takahiko AKIYAMA; Takao MORITA; Masahiro KUMEGAWA; Toshio NAGASE; Nobuaki UEHARA; Akio HOSHI

doi:10.1248/cpb.38.3164

Shoichiro OZAKI, Takahiko AKIYAMA, Takao MORITA, Masahiro KUMEGAWA, Toshio NAGASE, Nobuaki UEHARA, Akio HOSHI

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Keywords: 5'-O-acyl-5-fluorouridine, 5-fluorouracil, antitumor activity, 5-fluorouridine, L-1210 leukemia, synthesis

JOURNAL FREE ACCESS

1990 Volume 38 Issue 11 Pages 3164-3166

DOI https://doi.org/10.1248/cpb.38.3164

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Abstract

Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.

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