Nonsteroidal Antiinflammatory Agents. III. : Synthesis of the Metabolites of 10, 11-Dihydro-8, α-dimethyl-11-oxodibenz[b, f]oxepin-2-acetic Acid (Bermoprofen)

KATSUHIKO HINO; HIDEO NAKAMURA; SHIRO KATO; AKIRA IRIE; YASUTAKA NAGAI; HITOSHI UNO

doi:10.1248/cpb.36.3462

KATSUHIKO HINO, HIDEO NAKAMURA, SHIRO KATO, AKIRA IRIE, YASUTAKA NAGAI, HITOSHI UNO

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Keywords: metabolite

JOURNAL FREE ACCESS

1988 Volume 36 Issue 9 Pages 3462-3467

DOI https://doi.org/10.1248/cpb.36.3462

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Abstract

The metabolites (3 and 4) of 10, 11-dihydro-8, α-dimethyl-11-oxodibenz[b, f]oxepin-2-acetic acid (bermoprofen, AD-1590, 1), a promising antiinflammatory drug, were synthesized to confirm the proposed structures, and all the metabolites (2-4) were tested for activity in the carrageenin-induced edema test in rats. Metabolites 2 and 3 showed slight inhibition but 4 had no effect after intravenous administration.

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