Design and Synthesis of N-[N-[(S)-1-Ethoxycarbonyl-3-phenylprolyl]-L-alanyl]-N-(indan-2-yl)glycine (CV-3317), a New, Potent Angiotensin Converting Enzyme Inhibitor

AKIO MIYAKE; KATSUMI ITOH; YOSHIKAZU OKA

doi:10.1248/cpb.34.2852

AKIO MIYAKE, KATSUMI ITOH, YOSHIKAZU OKA

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Keywords: drug design

JOURNAL FREE ACCESS

1986 Volume 34 Issue 7 Pages 2852-2858

DOI https://doi.org/10.1248/cpb.34.2852

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Abstract

A new angiotensin converting enzyme (ACE) inhibitor, N-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycine (9a), was found as a result of extensive studies on the structural requisites for the C-terminal amino acid moiety in ACE inhibitors. The synthesis and the determination of the absolute configuration of 9a are described.

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