Structure Elucidation of the Bioactive Metabolites of ML-236B (Mevastatin) Isolated from Dog Urine

HIDEYUKI HARUYAMA; HARUMITSU KUWANO; TAKESHI KINOSHITA; AKIRA TERAHARA; TAKASHI NISHIGAKI; CHIHIRO TAMURA

doi:10.1248/cpb.34.1459

HIDEYUKI HARUYAMA, HARUMITSU KUWANO, TAKESHI KINOSHITA, AKIRA TERAHARA, TAKASHI NISHIGAKI, CHIHIRO TAMURA

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Keywords: mass spectrometry

JOURNAL FREE ACCESS

1986 Volume 34 Issue 4 Pages 1459-1467

DOI https://doi.org/10.1248/cpb.34.1459

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Abstract

Two active metabolites of ML-236B, 4β, 6α-dihydroxy ML-236B (M3, 2), and 3β-hydroxy ML-236B (M4, 3), were isolated from the urine of ML-236B-treated dogs. The structures of M3 and M4 were elucidated on the basis of spectral data and confirmed by X-ray analysis.

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