Synthesis of New Water-soluble Dihydropyridine Vasodilators

MASARU IWANAMI; TADAO SHIBANUMA; MASAHARU FUJIMOTO; RYUTARO KAWAI; KAZUHARU TAMAZAWA; TOICHI TAKENAKA; KOZO TAKAHASHI; MASUO MURAKAMI

doi:10.1248/cpb.27.1426

MASARU IWANAMI, TADAO SHIBANUMA, MASAHARU FUJIMOTO, RYUTARO KAWAI, KAZUHARU TAMAZAWA, TOICHI TAKENAKA, KOZO TAKAHASHI, MASUO MURAKAMI

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Keywords: vasodilators

JOURNAL FREE ACCESS

1979 Volume 27 Issue 6 Pages 1426-1440

DOI https://doi.org/10.1248/cpb.27.1426

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Abstract

Several kinds of water-soluble dihydropyridine vasodilators were prepared and their vasodilating activities were evaluated. Among them, 2-(N-benzyl-N-methylamino)-ethyl methyl 2, 6-dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate hydrochloride (YC-93) was found to have outstanding activity and bioavailability. Various synthetic routes for this compound were examined.

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