1974 Volume 22 Issue 9 Pages 2113-2117
Eleven acyl and alkyliden derivatives of pentenomycin I (I) were synthesized for obtaining an improved antibiotic. All derivatives synthesized showed same order of or improved antimicrobial activity than the natural antibiotic. Among these derivatives, 2-bromo-4, 5, 6-triacetylpentenomycin I (XIV) showed strongest antimicrobial activity.