未来食品科学 ›› 2021, Vol. 1 ›› Issue (4): 100-113.DOI: 10.12281/ffs2708-1893-20211011-008

• • 上一篇    

膳食花色苷防治阿尔兹海默病的潜在作用途径

范卓妍1, 李景明1, 杨新泉2,*   

  1. 1.中国农业大学食品科学与营养工程学院,北京 100083;2.广州大学生命科学学院,广东 广州 510006
  • 收稿日期:2021-09-11 修回日期:2021-09-17 接受日期:2021-09-30 出版日期:2021-12-15 发布日期:2021-10-15
  • 通讯作者: 杨新泉,Email:yangxq@gzhu.edu.cn
  • 作者简介:第一作者简介:范卓妍(1993—)(ORCID: 0000-0002-3784-5352),女,博士研究生,研究方向为食品营养。Email: Fzy2830@163.com
  • 基金资助:
    国家自然科学基金面上项目(32172210)

Underlying Mechanism of Dietary Anthocyantins in Prevention and Treatment of Alzheimer’s Disease

FAN Zhuoyan1, LI Jingming1, YANG Xinquan2,*   

  1. 1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; 2. School of Life Sciences, Guangzhou University, Guangzhou 510006, China
  • Received:2021-09-11 Revised:2021-09-17 Accepted:2021-09-30 Online:2021-12-15 Published:2021-10-15
  • Contact: YANG Xinquan,Email:yangxq@gzhu.edu.cn

摘要: 阿尔兹海默病(Alzheimer’s disease,AD)是严重威胁老年人健康的一种神经退行性疾病,近年来其发病率呈上升趋势,但有效治疗手段仍较少。膳食来源花色苷具有防治AD的广泛益处。本文综述了体外、细胞和动物实验以及人体实验中关于膳食花色苷防治AD的可能作用途径和机制,同时讨论了花色苷的生物利用度和生物转化以及跨越血脑屏障运输等情况。花色苷能够保护神经元、胶质细胞和海马神经细胞免受β淀粉样蛋白(amyloid β-protein,Aβ)和微管相关蛋白tau(microtubule-associated protein tau,tau)的损伤,减缓神经元凋亡。花色苷可调节小胶质细胞和星形胶质细胞的活性和功能,改变AD的发生和发展进程。此外,花色苷对肠道微生物代谢产物的影响或在其抗AD方面发挥不容忽视的作用。虽然膳食花色苷在人体中防治AD的健康作用尚未得到充分研究,但目前已有相关证据显示膳食花色苷可能是防治AD的有效膳食补充剂。

关键词: 膳食花色苷, 阿尔兹海默病, 神经细胞凋亡, 神经胶质细胞, 肠道微生物

Abstract: Alzheimer's disease(AD) is a neurodegenerative disease that seriously threatens the health of the elderly population. The incidence rate of AD is on the rise, whereas hardly any effective treatment is available. Dietary anthocyanins presents the potential benefits in the prevention and treatment of AD. This review summarizes the main findings, possible action pathways and mechanisms of anthocyanins in the prevention and treatment of AD performed in vitro, cellular and animal studies, as well as human trials. Meanwhile, the bioavailability, biotransformation and transportation across the blood-brain barrier of anthocyanins are discussed. Anthocyanins can protect neurons and glial cells from the damage of Aβ and tau protein, and alleviate neuronal apoptosis. Anthocyanins can regulate the phenotype and function of microglia and astrocytes, and thus affect the occurrence and development of AD. In addition, the effects of anthocyanins on intestinal microbial metabolites may play important role in anti-AD. Although the health effects of anthocyanins in the treatment of AD in human trials are not sufficient yet, the evidence accumulated indicates that anthocyanins may be an effective dietary supplement for the prevention and treatment of AD.

Key words: anthocyanins, Alzheimer’s disease, neuronal apoptosis, glial cells, intestinal microbes

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