中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (2): 129-133.doi: 10.12144/zgmfskin202302129

• 综述 • 上一篇    下一篇

TRP通道在炎症性皮肤病中的作用

洪安澜1,林彤2   

  1. 1中国医学科学院北京协和医学院皮肤病医院（研究所）激光科，江苏南京，210042;

    2中国医学科学院北京协和医学院皮肤病医院(研究所)江苏省皮肤病与性病分子生物学重点实验室，江苏南京，210042

  • 出版日期:2023-02-15 发布日期:2022-12-28

Update of the role for TRP channels in inflammatory skin diseases

HONG Anlan1, LIN Tong2   

  1. 1 Department of Cosmetic Laser Surgery, Hospital for Skin Diseases ( Institute of Dermatology)，Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042，China; 2 Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and Sexually Transmitted Infections, Hospital for Skin Diseases ( Institute of Dermatology)，Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2023-02-15 Published:2022-12-28

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摘要： 瞬时受体电位（TRP）通道是一类非特异性阳离子通道蛋白家族，在皮肤感觉神经元和非神经元细胞中广泛表达，能被多种刺激激活，参与炎症性皮肤病的发生发展。本文重点对TRP通道的不同亚型在玫瑰痤疮、特应性皮炎、银屑病、接触性皮炎等炎症性皮肤病中的作用进行综述，提示TRP通道有望成为炎症性皮肤病的潜在治疗靶点。

关键词: 瞬时受体电位通道, 炎症性皮肤病, 玫瑰痤疮, 银屑病, 特应性皮炎

Abstract: Transient receptor potential (TRP) channel is a family of nonspecific cationic channel proteins, which are widely expressed in sensory neurons and non-neuronal cells of skin. TRP channels can be activated by a variety of stimuli, thus participating in the occurrence and development of inflammatory skin diseases. This review focuses on the role of different TRP channel subtypes in inflammatory skin diseases such as rosacea, atopic dermatitis, psoriasis and contact dermatitis, suggesting that TRP channels may be potential therapeutic targets for inflammatory skin diseases.

Key words: transient receptor potential channel, inflammatory skin disease, rosacea, psoriasis, atopic dermatitis