关键词: 关节炎, 类风湿；骨质疏松；骨密度；中年人；老年人；女性

Abstract: Objective　To explore the clinical features of bone loss in middle-aged and elderly women with rheumatoid arthritis（RA）.Methods　 All the participants were enrolled from Sichuan Provincial People's Hospital between August 2008 and June 2016，including 543 female patients aged ≥40 years receiving a definite diagnosis of RA（RA group） from Rheumatology and Immunology Clinic，and 1 742 age-matched healthy female controls undergoing physical examination（control group）. BMD of the lumbar spine （L1-4） in the frontal position，left femoral neck，Ward's triangle of the left hip，great trochanter of the left femur，shaft of left femur and total hip bone，and prevalence of osteoporosis（OP） at lumbar spine and femur were compared between the groups by age group. Results　 RA was associated with much lower mean BMD of L1 to L4 vertebrae in age groups of 40-49 and 50-59（P<0.05），but showed no association with the mean BMD of L1 to L4 vertebrae in age groups of 60-69，70-79 and ≥80 （P>0.05）. Moreover，RA was found to be associated with obviously lower mean BMD of left femoral neck，great trochanter of the left femur，Ward's triangle of the left hip，shaft of left femur and total hip bone in age groups of 40-49，50-59，60-69（P<0.05），but demonstrated no association with the mean BMD of the above 5 regions in age group of ≥80（P>0.05）. RA was correlated with higher prevalence of OP at the lumbar spine and femur in age group of 40-49 and 50-59，and higher prevalence of OP at the femur in age groups of 60-69（P<0.05），while showed no correlation with the prevalence of OP at the lumbar spine in age groups of 60-69 as well as the prevalence of OP at the lumbar spine and femur in age groups of 70-79 and ≥80（P>0.05）.Conclusion　 RA could increase the risk of having bone loss and OP. Moreover，its impact varied differently by age and anatomic region. Furthermore，focused attention should be paid to the prevention and treatment of OP in middle-aged and elderly women.

Key words: Arthritis, rheumatoid；Osteoporosis；Bone mineral density；Middle aged；Aged；Women