Objective To investigate the CT manifestations of sclerosing angiomatoid nodular transformation of the spleen (SANT). Methods The CT and clinical data of 7 cases with SANT proved by pathology were analyzed retrospectively, and the related literatures were reviewed. Results All 7 cases were single lesion, among which 6 were oval and 1 case had irregular shape. The diameter of the focus ranged from 3.8 cm to 8.9 cm, with the mean value of 6.9 cm. CT plain scan showed 2 cases with uniform low density and clear boundary, and the remaining 5 cases were dominated by a slightly lower density, with strip isodensity in the interior and edge, and the boundaries were not clear. On dynamic enhanced CT, 7 cases showed early enhancement of the edge and interior of the focus in artery phase, and continuous centripetal enhancement in portal vein and delayed phase. Among whom, 5 cases showed obvious“spoke wheel sign” especially in portal-vein phase, and clear boundary on enhanced CT. The spleen was swelling in the area of the focus in 6 cases, and local protrusion occurred in 2 cases. Ascites, invasion or metastasis of adjacent structures, or enlarged lymph node of abdominal cavity and retroperitoneum could not be observed in any of the 7 cases. Conclusion The CT manifestation of SANT has certain characteristics, most of which are single large round or oval mass of spleen with equal or low density on unenhanced CT. The peripheral and internal area show obvious enhancement as nodular or strip in the early stage of enhanced CT, with continued obvious enhancement in delayed stage, and“spoke wheel sign” can be observed  in some cases, which is of great value for the diagnosis and identification of SANT.