关键词: 急性胰腺炎, 高甘油三脂血症, 血流动力学, 丙硫氧灭定, 大鼠

Abstract:

Abstract objective To explore the role of Propyl thioxime on hyperlipidemic acute pancreatitis (AP), and to explore the mechanism of hyperlipidemia in the occurrence of AP. Methods Fifty male Wister rats were randomly divided into 4 groups: control group (Bal group, 10), pancreatitis sensitized model group (M group, 10), high-fat+model group (H+M group, 15), Lipid-lowering+model group (L+M group, 15). The pancreatic artery blood flow velocity was measured, blood flow was calculated, blood samples were taken for determination of serum amylase (AMY), triglyceride (TG) and free fatty acid (FFA), and pancreas pathological examination was performed. Results The FFA and AMY in M group were significantly higher than those in Bal group (P<0.05). The levels of TG, FFA and AMY in H+M group were significantly higher than those in Bal group and M group (P<0.05). The rats in L+M group had significantly lower TG levels than those in Bal group, M group and H+M
group (P<0.05), but FFA level significantly increased (P<0.05), and AMY level was not significantly different between H+M group and L+M group (P>0.05); the incidences of pancreatitis in the H+M and L+M group were significantly different from that in the M group; the decrease degrees of pancreatic arterial blood flow velocity in the H+M group and L+M group were most obvious, which were significantly different from Bal group and M group (P<0.05). Conclusion Our study shows that hyperlipidemia can increase the incidence of pancreatitis in pancreatitis sensitized model rats, and Propyl thioxime does not reduce the incidence of pancreatitis.

Key words: acute pancreatitis, hypertriglyceridemia, hemodynamics, Propyl thioxime, rats