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Peripersonal space plasticity, Self-disorders and intersubjectivity in patients with early-onset and adult-onset schizophrenia

Published online by Cambridge University Press:  19 July 2023

V. Lucarini ,
F. Magnani ,
F. Giustozzi ,
R. Volpe ,
F. Ferroni ,
M. Ardizzi ,
N. Fascendini ,
S. Amorosi ,
F. Rasmi  and
C. Marchesi
...Show all authors
V. Lucarini*
Affiliation:
Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Université Paris Cité C’JAAD, Evaluation, Prevention and Therapeutic Innovation Department, GHU Paris Psychiatrie et Neurosciences Institut de Psychiatrie, CNRS GDR 3557, Paris, France
F. Magnani
Affiliation:
Psychiatry Unit
F. Giustozzi
Affiliation:
Psychiatry Unit
R. Volpe
Affiliation:
Psychiatry Unit
F. Ferroni
Affiliation:
Unit of Neuroscience, University of Parma, Parma, Italy
M. Ardizzi
Affiliation:
Unit of Neuroscience, University of Parma, Parma, Italy
N. Fascendini
Affiliation:
Psychiatry Unit
S. Amorosi
Affiliation:
Psychiatry Unit
F. Rasmi
Affiliation:
Psychiatry Unit
C. Marchesi
Affiliation:
Psychiatry Unit
V. Gallese
Affiliation:
Unit of Neuroscience, University of Parma, Parma, Italy
M. Tonna
Affiliation:
Psychiatry Unit
*
*Corresponding author.

Abstract

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Introduction

In schizophrenia, there is evidence for anomalies in the extension and plasticity of the peripersonal space (PPS), the portion of space surrounding our body, plastically shaped through motor experiences. An impaired multisensory integration at the PPS level would underpin the disembodiment, a core feature of the disorder linked to subjective perturbations of the sense of self (“Self-disorders”) and of the intersubjective dimension (“schizophrenic autism”).

Objectives

The present study was aimed at: 1) exploring possible associations between PPS data, psychopathological dimensions, and subjective experiences in schizophrenia; 2) identifying a specific PPS profile in patients with early-onset schizophrenia.

Methods

A motor training with a tool was used to assess the PPS size and boundaries demarcation in twenty-seven schizophrenia outpatients. Moreover, they underwent a thorough psychopathological evaluation with the Positive And Negative Syndrome Scale (PANSS), the Examination of Anomalous Self Experience scale (EASE) and the Autism Rating Scale (ARS). Subsequently, the sample was divided into early (EOS) and adult-onset (AOS) subgroups, that were compared with respect to their PPS and psychopathological profiles.

Results

PPS features (size and boundaries demarcation) were associated with PANSS negative score, subjective experiences of existential reorientation (EASE Domain 5 scores) and traits of schizophrenic autism (ARS scores; Fig. 1). PPS parameters (Fig. 2) and ARS scores, but not PANSS and EASE differentiated between early and adult-onset subgroups.

Image:

Image 2:

Conclusions

Our results suggest a link between PPS patterns, negative symptoms, and disturbances of the subjective experience, particularly in the intersubjective domain, in schizophrenia. Moreover, they candidate specific PPS profiles and schizophrenic autism traits as EOS markers.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S492 - S493
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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