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Peripheral endocannabinoids in eating disorders and obesity and its relationship with clinical and anthropometric variables

Published online by Cambridge University Press:  13 August 2021

I. Baenas-Soto ,
R. Miranda-Olivos ,
L. Vos ,
R. Granero ,
I. Sánchez ,
N. Riesco ,
A. Del Pino-Gutiérrez ,
E. Codina ,
J. A. Fernández-Formoso  and
N. Vilarrasa
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I. Baenas-Soto*
Affiliation:
Psychiatry, Bellvitge Hospital - IDIBELL, Barcelona, Spain
R. Miranda-Olivos
Affiliation:
Psychiatry, Bellvitge Hospital - IDIBELL, Barcelona, Spain
L. Vos
Affiliation:
Medicina, Universidad Barcelona, Barcelona, Spain
R. Granero
Affiliation:
Department Of Psychobiology And Methodology, Autonomous University of Barcelona, Barcelona, Spain
I. Sánchez
Affiliation:
Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Instituto de Salud Carlos III, Madrid, Spain
N. Riesco
Affiliation:
Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Instituto de Salud Carlos III, Madrid, Spain
A. Del Pino-Gutiérrez
Affiliation:
Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Instituto de Salud Carlos III, Madrid, Spain
E. Codina
Affiliation:
Department Of Public Health, Mental Health And Perinatal Nursing, School Of Nursing, University of Barcelona, Barcelona, Spain
J. A. Fernández-Formoso
Affiliation:
Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Instituto de Salud Carlos III, Madrid, Spain
N. Vilarrasa
Affiliation:
Ciberdem-ciber De Diabetes Y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Madrid, Spain
N. Virgili
Affiliation:
Department Of Endocrinology And Nutrition, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain
R. Lopez-Urdiales
Affiliation:
Department Of Endocrinology And Nutrition, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain
A. Pastor
Affiliation:
Integrative Pharmacology And Systems Neuroscience Research Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain
R. De La Torrre
Affiliation:
Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Instituto de Salud Carlos III, Madrid, Spain Integrative Pharmacology And Systems Neuroscience Research Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain Department Of Experimental And Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Barcelona, Spain
S. Jimenez-Murcia
Affiliation:
Psychiatry, University Hospital Bellvitge-IDIBELL and CIBEROBN, Barcelona, Spain Department Of Psychiatry, University Hospital of Bellvitge-IDIBELL, CIBERobn, University of Barcelona, Barcelona, Spain
C. Soriano-Mas
Affiliation:
Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain
F. Fernandez-Aranda
Affiliation:
Psychiatry, University Hospital Bellvitge-IDIBELL and CIBERobn, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) play a pivotal role in food intake and reward aspects of feeding. Aberrant functioning in the endocannabinoid system has been observed in patients with eating disorders (EDs). This dysfunction may influence the incentive processes stimulating behaviors towards food acquisition or the hedonic evaluation of ingested food.

Objectives

The aims of this study are to compare fasting peripheral levels of AEA and 2-AG in ED patients, obese subjects (OB) and healthy controls (HCs), and to explore their association with clinical and anthropometric variables.

Methods

The sample included a total of 63 adult women. Peripheral blood samples were collected to investigate fasting levels of AEA and 2-AG in 31 ED patients: 22 Anorexia Nervosa (AN) and 9 Binge Eating Disorder (BED), compared to 21 OB and 11 HCs. Several clinical and anthropometric variables were also assessed.

Results

Comparing groups, significant differences in AEA levels were found (p=0.001). Specifically, individuals with AN exhibited lower AEA than OB (p<0.001) and BED (p=0.007), while OB showed higher AEA than HCs (p=0.015). 2-AG was positively correlated with hostility dimension in EDs and negatively associated with impulsive traits in OB. AEA showed a direct association with body dissatisfaction in AN, contrary to OB. Finally, in AN, AEA negatively correlated with the body mass index, while 2-AG was positively associated with the fat mass.

Conclusions

These results suggest an interaction between biological and clinical factors defining a vulnerability pathway that could help fitting personalized therapeutic approaches in each condition.

Disclosure

No significant relationships.

Keywords

Anandamideeating disordersobesity2-Arachidonoylglycerol
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S115
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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