EXPERIMENTAL CHRONIC "EPILEPSY" IN THE BABOON AND EPILEPTIFORM SEIZURES IN THE DOG, RABBIT AND GUINEA PIG
Abstract
Experimental chronic "epilepsy" has been produced in the baboon and African green monkey by a single application of alumina cream to the motor cortex. After a clinically free period, reactions first occurred 7 weeks and 3 months, respectively, after operation. These observations parallel the results obtained previously in a large series of rhesus monkeys.
Rabbits similarly treated reacted 3-4 weeks after operation with acute convulsive attacks of short duration.
Recurrent epileptiform seizures were induced in the guinea pig following an intra-cerebral injection of the same material. The convulsive pattern differed from that observed in the primates. Dogs and cats failed to respond to the cerebral application of alumina cream. However, alumina A caused immediate acute convulsions in dogs, but produced no seizures in cats.
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