Dissipative Particle Dynamics Simulation on Paclitaxel Loaded PEO–PPO–PEO Block Copolymer Micelles
Self-assembly behavior of the polymer drug loading micelle PEO–PPO–PEO was studied using dissipative particle dynamics (DPD) simulation method with various simulation steps. The distributions of drugs in polymer carriers were also investigated with different drug feed ratios.
Polymer carriers distributed on the surface of the spherical micelle, and drugs were almost encapsulated in the inner of the micelle. Our simulation work demonstrates that the DPD simulation is effective to study the drug loaded systems and can give useful guidance on the design and preparation
of new drug carriers with tailored properties.
Document Type: Research Article
Publication date: 01 March 2014
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