![logo](/images/journal-logos/asp/jcc.gif)
Pioglitazone Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles-Surface Coated by Chitosan to Improve Kinetics
The purpose of this work was to develop Pioglitazone loaded surface modified Poly(lactic-co-glycolic acid) (PLGA) nanoparticles. The desired surface modified PLGA nanospheres loaded with Pioglitazone were prepared by the emulsion solvent evaporation method. Formed nanospheres were subjected
to various studies for characterization including Photon Correlation Spectroscopy (PCS), Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD). These studies favorably revealed that the mean particle diameter of optimized formulation was 154 nm and had spherical morphology with amorphous
nature. Zeta potential analyzer confirms the surface modification of nanoparticles. Moreover, these particles were also subjected to Fourier Transform Infra Red Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Thermo Gravimetric Analysis (TGA) for compatibility analysis between
drug and polymer. The results were positive and showed that, there were no interaction between drug and polymer. HPTLC method has been developed for the quantitative and qualitative estimation of drug in nanoparticle formulation. The optimized formulation demonstrated favorable in-vitro prolonged
release characteristics. The mean residence time of formulation was also increased significantly (P < 0.05) when compared with normal drug during pharmacokinetic evaluation. The in-vivo toxicity study in albino rats showed no significant change in bio chemical and pathological examinations.
Hence, the designed system could possibly be advantageous in terms of prolonged release, to achieve reduced dose frequency and improve patient compliance of Pioglitazone. Surface modified Pioglitazone loaded PLGA nanospheres showed beneficial characteristics when compared with Pioglitazone
loaded PLGA nanospheres.
Keywords: CHITOSAN; EMULSION SOLVENT EVAPORATION METHOD; NANOPARTICLE; PIOGLITAZONE; PLGA
Document Type: Research Article
Publication date: 01 September 2013
- Journal of Chitin and Chitosan Science (JCC) is an international peer-reviewed journal that covers all aspects of chitin and chitosan based biomaterials and their derivatives, their sources, commercial production, processing, spectroscopic characterization, biochemistry, biology, enzymology, ecology, chemical and physico-chemical properties, biological activities, medical and biomedical applications such as drug delivery systems, gene delivery, pharmaceuticals, tissue engineering, wound healing agents, antimicrobial activities, biotextiles, biocatalysis, food science, agriculture, water purification, environment, and other areas of life sciences and materials science.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Aims and Scope
- Ingenta Connect is not responsible for the content or availability of external websites
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content