Early Predictors of the Endometrium Cancer Recurrence in Our Environment

Lopez Gonzalez Elga; Montero Venegas Francisco Manuel; Camacho Carrasco Maria

doi:doi:10.11648/j.jctr.20210902.11

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Early Predictors of the Endometrium Cancer Recurrence in Our Environment

Lopez Gonzalez Elga, Montero Venegas Francisco Manuel, Camacho Carrasco Maria

Published in Journal of Cancer Treatment and Research (Volume 9, Issue 2)

Received: 26 May 2021 Accepted: 8 June 2021 Published: 16 June 2021

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Abstract

Objective: to find out the predictors in the recurrence of the illness in patients suffering from endometrium cancer at the differet stages of it. Material and Method: Retrospective study of 170 patients who were diagnosed with endometrium cancer between 2013-2017 at “Juan Ramon Jimenez” Hospital in Huelva. Variables such us age, degree of tumour differentation, miometrial invasion (MI), post surgical staging and lympho-vascular space infiltration (LVSI) were analysed in all those patients that had recurrences during the period of the study. The study was sone by using SPSS 23rd V. Once the analysis of Kolmorov-Smirnov concluded in an unusual result; the Chi-Squared test was used in order to obtain parametric categorical data; whereas the U (by Mann Whitney) test was used for the non-parametric data. P<0.01 was accepted as significant from a statistic point of view. results: During the study, 9 patients were diagnosed with tumoral affects recurrence. This means 5.3 % out of the whole sample. The statistic analysis concluded that there is no relation of dependence among the recurrence varible and the Miometrial Invasion variable (χ2=4.780,p=0.092) recurrence and Tumor grade (χ2=7.765, p=0.051) and recurrence and post surgical (χ2=10.200, p=0.070). On the contrary, it is stated that there is a relation of dependence among lymph-node damage variable and LSVI+(χ2=9.954, Cc=0.235, p<.01). The existence of LSVI was evaluated in all the patients. lVSI was negative in 141 cases and 4 of these cases had recurrence of the illness 55.5 % of the patients in which the illness recurred had positive LVSI (5 out of 9). Conclusions: our results proved that more than a half of the patients with recurrence of the illness have Lympho-vascular infiltration and also; if the LVSI is negative, there is a risk of 2.8% of having recurrence. Although it would be neccessary to carry out prospective multi-center studies, this preliminary study determines an obvious relation between LVSI and the recurrence in a short or long term period. Again, The variable that stablishes the LVSI can be a relevant datum when dealing with the staging process of the endometrium cancer, apart from being very useful in the prediction of the illness recurrence.

Published in	Journal of Cancer Treatment and Research (Volume 9, Issue 2)
DOI	10.11648/j.jctr.20210902.11
Page(s)	22-26
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cancer, Endometrium, Laparoscopy, Lymphovascular Infiltration, Lymphadenectomy, Survival

References

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[2]	Endometrial cancer. En: Callahan TL, Caughey AB, editores. Blueprint’s obstetrics and gynecology, 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. p. 310–6.
[3]	Ramondetta LM, Burke TW, Broaddus R. Treatment of endometrial cancer. In: Aman UB, Ralph SF (editors). Gynecologic Cancer. M. D. Anderson. Cancer Care Series. USA: Springer; 2006. p. 148-174.
[4]	Zaino RJ. Introduction to Endometrial Cancer. In: Giordano A, Bovicelli A, Kurman RJ (editors). Molecular Pathology of Gynecologic Cancer. USA: Humana Press; 2007. p. 51-100.
[5]	Zhang H, Zuo Z, Wang Y, Wang L, Cohort study evaluating paraaortic lymphadenectomy in endometrial cancer. Oncol Lett. 2012; 4 (6): 1361-5.
[6]	Convery PA, Cantrell LA, Di Santo N, Broadwater G, et al. Retrospective review of an intraoperative algorithm to predict lymph node metastasis in low-grade endometrial adenocarcinoma. Gynecol Oncol. 2011; 123 (1): 65-70.
[7]	Alay I, Turan T, Ureyen I, Karalok A, et al. Lymphadenectomy should be performed up to the renal vein in patients with intermediate-high risk endometrial cancer. Pathol Oncol Res. 2015; 21 (3): 803-10.
[8]	Hahn HS, Lee IH, Kim TJ, Lee KH, et al. Lymphovascular space invasion is highly associated with lymph node metastasis and recurrence in endometrial cancer. Aust N Z J Obstet Gynaecol. 2013; 53 (3): 293-7.
[9]	Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009; 105 (2): 103-4. https://doi.org/10.1016/j.ijgo.2009.02.012.
[10]	Balagueró L, Comino R, Sainz de la Cuesta R, Jurado M, Xercavins J, Petschen I. Carcinoma de endometrio. Documento de Consenso SEGO. Madrid: Sociedad Española de Ginecología y Obstetricia; 1999. p. 91–136. https://doi.org/10.1016/j.gine.2009.03.009.
[11]	Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006; 10 (29): 4783-91. https://doi.org/10.1200/JCO.2006.06.7173.
[12]	Sanhueza P, Oliva L. Eficiencia de los métodos diagnósticos en el estudio del sangrado uterino anormal en la peri y post menopausia. Rev Chil Obstet Ginecol 2008; 73 (1): 58-62. https://dx.doi.org/10.4067/S0717-75262008000100010.
[13]	Tabor A, Watt HC, Wald NJ. Endometrial thickness as a test for endometrial cancer in women with postmenopausal vaginal bleeding. Obstet Gynecol 2002; 99 (4): 663-70. https://doi.org/10.1016/S0029-7844(01)01771-9.
[14]	J. A. Lachance, E. N. Everett, B. Greer, L. Mandel, E. Swisher, H. Tamini, et al. The effect of age on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. Gynecol Oncol, 101 (2006), pp. 470-475. https://doi.org/10.1016/j.ygyno.2005.11.009.
[15]	Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012; 62 (4): 220-41. https://doi.org/10.3322/caac.21149.

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Lopez Gonzalez Elga, Montero Venegas Francisco Manuel, Camacho Carrasco Maria. (2021). Early Predictors of the Endometrium Cancer Recurrence in Our Environment. Journal of Cancer Treatment and Research, 9(2), 22-26. https://doi.org/10.11648/j.jctr.20210902.11

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ACS Style

Lopez Gonzalez Elga; Montero Venegas Francisco Manuel; Camacho Carrasco Maria. Early Predictors of the Endometrium Cancer Recurrence in Our Environment. J. Cancer Treat. Res. 2021, 9(2), 22-26. doi: 10.11648/j.jctr.20210902.11

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AMA Style

Lopez Gonzalez Elga, Montero Venegas Francisco Manuel, Camacho Carrasco Maria. Early Predictors of the Endometrium Cancer Recurrence in Our Environment. J Cancer Treat Res. 2021;9(2):22-26. doi: 10.11648/j.jctr.20210902.11

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@article{10.11648/j.jctr.20210902.11,
  author = {Lopez Gonzalez Elga and Montero Venegas Francisco Manuel and Camacho Carrasco Maria},
  title = {Early Predictors of the Endometrium Cancer Recurrence in Our Environment},
  journal = {Journal of Cancer Treatment and Research},
  volume = {9},
  number = {2},
  pages = {22-26},
  doi = {10.11648/j.jctr.20210902.11},
  url = {https://doi.org/10.11648/j.jctr.20210902.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20210902.11},
  abstract = {Objective: to find out the predictors in the recurrence of the illness in patients suffering from endometrium cancer at the differet stages of it. Material and Method: Retrospective study of 170 patients who were diagnosed with endometrium cancer between 2013-2017 at “Juan Ramon Jimenez” Hospital in Huelva. Variables such us age, degree of tumour differentation, miometrial invasion (MI), post surgical staging and lympho-vascular space infiltration (LVSI) were analysed in all those patients that had recurrences during the period of the study. The study was sone by using SPSS 23rd V. Once the analysis of Kolmorov-Smirnov concluded in an unusual result; the Chi-Squared test was used in order to obtain parametric categorical data; whereas the U (by Mann Whitney) test was used for the non-parametric data. P<0.01 was accepted as significant from a statistic point of view. results: During the study, 9 patients were diagnosed with tumoral affects recurrence. This means 5.3 % out of the whole sample. The statistic analysis concluded that there is no relation of dependence among the recurrence varible and the Miometrial Invasion variable (χ2=4.780,p=0.092) recurrence and Tumor grade (χ2=7.765, p=0.051) and recurrence and post surgical (χ2=10.200, p=0.070). On the contrary, it is stated that there is a relation of dependence among lymph-node damage variable and LSVI+(χ2=9.954, Cc=0.235, p<.01). The existence of LSVI was evaluated in all the patients. lVSI was negative in 141 cases and 4 of these cases had recurrence of the illness 55.5 % of the patients in which the illness recurred had positive LVSI (5 out of 9). Conclusions: our results proved that more than a half of the patients with recurrence of the illness have Lympho-vascular infiltration and also; if the LVSI is negative, there is a risk of 2.8% of having recurrence. Although it would be neccessary to carry out prospective multi-center studies, this preliminary study determines an obvious relation between LVSI and the recurrence in a short or long term period. Again, The variable that stablishes the LVSI can be a relevant datum when dealing with the staging process of the endometrium cancer, apart from being very useful in the prediction of the illness recurrence.},
 year = {2021}
}

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TY - JOUR
T1 - Early Predictors of the Endometrium Cancer Recurrence in Our Environment
AU - Lopez Gonzalez Elga
AU - Montero Venegas Francisco Manuel
AU - Camacho Carrasco Maria
Y1 - 2021/06/16
PY - 2021
N1 - https://doi.org/10.11648/j.jctr.20210902.11
DO - 10.11648/j.jctr.20210902.11
T2 - Journal of Cancer Treatment and Research
JF - Journal of Cancer Treatment and Research
JO - Journal of Cancer Treatment and Research
SP - 22
EP - 26
PB - Science Publishing Group
SN - 2376-7790
UR - https://doi.org/10.11648/j.jctr.20210902.11
AB - Objective: to find out the predictors in the recurrence of the illness in patients suffering from endometrium cancer at the differet stages of it. Material and Method: Retrospective study of 170 patients who were diagnosed with endometrium cancer between 2013-2017 at “Juan Ramon Jimenez” Hospital in Huelva. Variables such us age, degree of tumour differentation, miometrial invasion (MI), post surgical staging and lympho-vascular space infiltration (LVSI) were analysed in all those patients that had recurrences during the period of the study. The study was sone by using SPSS 23rd V. Once the analysis of Kolmorov-Smirnov concluded in an unusual result; the Chi-Squared test was used in order to obtain parametric categorical data; whereas the U (by Mann Whitney) test was used for the non-parametric data. P<0.01 was accepted as significant from a statistic point of view. results: During the study, 9 patients were diagnosed with tumoral affects recurrence. This means 5.3 % out of the whole sample. The statistic analysis concluded that there is no relation of dependence among the recurrence varible and the Miometrial Invasion variable (χ2=4.780,p=0.092) recurrence and Tumor grade (χ2=7.765, p=0.051) and recurrence and post surgical (χ2=10.200, p=0.070). On the contrary, it is stated that there is a relation of dependence among lymph-node damage variable and LSVI+(χ2=9.954, Cc=0.235, p<.01). The existence of LSVI was evaluated in all the patients. lVSI was negative in 141 cases and 4 of these cases had recurrence of the illness 55.5 % of the patients in which the illness recurred had positive LVSI (5 out of 9). Conclusions: our results proved that more than a half of the patients with recurrence of the illness have Lympho-vascular infiltration and also; if the LVSI is negative, there is a risk of 2.8% of having recurrence. Although it would be neccessary to carry out prospective multi-center studies, this preliminary study determines an obvious relation between LVSI and the recurrence in a short or long term period. Again, The variable that stablishes the LVSI can be a relevant datum when dealing with the staging process of the endometrium cancer, apart from being very useful in the prediction of the illness recurrence.
VL - 9
IS - 2
ER -

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Author Information

Lopez Gonzalez Elga

Juan Ramon Jimenez Hospital, Huelva, Spain
Montero Venegas Francisco Manuel

Juan Ramon Jimenez Hospital, Huelva, Spain
Camacho Carrasco Maria

Juan Ramon Jimenez Hospital, Huelva, Spain

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APA Style

Lopez Gonzalez Elga, Montero Venegas Francisco Manuel, Camacho Carrasco Maria. (2021). Early Predictors of the Endometrium Cancer Recurrence in Our Environment. Journal of Cancer Treatment and Research, 9(2), 22-26. https://doi.org/10.11648/j.jctr.20210902.11

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ACS Style

Lopez Gonzalez Elga; Montero Venegas Francisco Manuel; Camacho Carrasco Maria. Early Predictors of the Endometrium Cancer Recurrence in Our Environment. J. Cancer Treat. Res. 2021, 9(2), 22-26. doi: 10.11648/j.jctr.20210902.11

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AMA Style

Lopez Gonzalez Elga, Montero Venegas Francisco Manuel, Camacho Carrasco Maria. Early Predictors of the Endometrium Cancer Recurrence in Our Environment. J Cancer Treat Res. 2021;9(2):22-26. doi: 10.11648/j.jctr.20210902.11

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@article{10.11648/j.jctr.20210902.11,
  author = {Lopez Gonzalez Elga and Montero Venegas Francisco Manuel and Camacho Carrasco Maria},
  title = {Early Predictors of the Endometrium Cancer Recurrence in Our Environment},
  journal = {Journal of Cancer Treatment and Research},
  volume = {9},
  number = {2},
  pages = {22-26},
  doi = {10.11648/j.jctr.20210902.11},
  url = {https://doi.org/10.11648/j.jctr.20210902.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20210902.11},
  abstract = {Objective: to find out the predictors in the recurrence of the illness in patients suffering from endometrium cancer at the differet stages of it. Material and Method: Retrospective study of 170 patients who were diagnosed with endometrium cancer between 2013-2017 at “Juan Ramon Jimenez” Hospital in Huelva. Variables such us age, degree of tumour differentation, miometrial invasion (MI), post surgical staging and lympho-vascular space infiltration (LVSI) were analysed in all those patients that had recurrences during the period of the study. The study was sone by using SPSS 23rd V. Once the analysis of Kolmorov-Smirnov concluded in an unusual result; the Chi-Squared test was used in order to obtain parametric categorical data; whereas the U (by Mann Whitney) test was used for the non-parametric data. P<0.01 was accepted as significant from a statistic point of view. results: During the study, 9 patients were diagnosed with tumoral affects recurrence. This means 5.3 % out of the whole sample. The statistic analysis concluded that there is no relation of dependence among the recurrence varible and the Miometrial Invasion variable (χ2=4.780,p=0.092) recurrence and Tumor grade (χ2=7.765, p=0.051) and recurrence and post surgical (χ2=10.200, p=0.070). On the contrary, it is stated that there is a relation of dependence among lymph-node damage variable and LSVI+(χ2=9.954, Cc=0.235, p<.01). The existence of LSVI was evaluated in all the patients. lVSI was negative in 141 cases and 4 of these cases had recurrence of the illness 55.5 % of the patients in which the illness recurred had positive LVSI (5 out of 9). Conclusions: our results proved that more than a half of the patients with recurrence of the illness have Lympho-vascular infiltration and also; if the LVSI is negative, there is a risk of 2.8% of having recurrence. Although it would be neccessary to carry out prospective multi-center studies, this preliminary study determines an obvious relation between LVSI and the recurrence in a short or long term period. Again, The variable that stablishes the LVSI can be a relevant datum when dealing with the staging process of the endometrium cancer, apart from being very useful in the prediction of the illness recurrence.},
 year = {2021}
}

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