A 78-year-old female was admitted to our hospital due to constipation and positive fecal occult blood test. Colonoscopy revealed four large sessile polyps with typical lobulated surface configuration at the cecum (20mm in size) , the ascending (20mm in size) , the right side transverse (20mm in size) and the left side transverse colon (30mm in size) , respectively. All tumors were removed using endoscopic mucosal resections. Histopathology of 4 tumors revealed focal adenocarcinoma in adenoma. In our present study, the incidence of case with multiple synchronous such tumors was only 4% (6/149) .